Treatment Outcome for Gastric Mucosa-Associated Lymphoid Tissue Lymphoma according to Helicobacter pylori Infection Status: A Single-Center Experience

BACKGROUND/AIMS: Helicobacter pylori eradication therapy has been used as a first-line treatment for H. pylori-positive gastric mucosa-associated lymphoid tissue (MALT) lymphoma. However, the management strategy for H. pylori-negative MALT lymphoma remains controversial. Therefore, the aim of this study was to examine the success rate of each treatment option for H. pylori-positive and H. pylori-negative gastric MALT lymphomas. METHODS: In total, 57 patients with gastric MALT lymphoma diagnosed between December 2000 and June 2012 were enrolled in the study. The treatment responses were compared between H. pylori-positive and H. pylori-negative gastric MALT lymphomas. RESULTS: Of the 57 patients, 43 (75%) had H. pylori infection. Forty-eight patients received H. pylori eradication as a first-line treatment, and complete remission was achieved in 31 of the 39 patients (80%) with H. pylori-positive MALT lymphoma and in five (56%) of the nine patients with H. pylori-negative MALT lymphoma; no significant difference was observed between the groups (p=0.135). The other treatment modalities, including radiation therapy, chemotherapy, and surgery, were effective irrespective of H. pylori infection status, with no significant difference in the treatment response between H. pylori-positive and H. pylori-negative MALT lymphomas. CONCLUSIONS: H. pylori eradication therapy may be considered as a first-line treatment regardless of H. pylori infection status.

The effect of statins on HDL-cholesterol in type 2 diabetic patients / 대한내과학회지

BACKGROUND/AIMS: Statins have been a mainstay of treatment for primary and secondary prevention of coronary heart disease through their beneficial effect on lipid profile. However, their effect on the HDL cholesterol level has been determined to be equivocal or unclear. This study sought to investigate HDL cholesterol response to statin treatment in type 2 diabetic patients. METHODS: We retrospectively assessed the effect of statins in 217 patients with type 2 diabetes and dyslipidemia through chart review. Patients who were using medications such as fibrates, niacin, or thiazolidinediones, or had a plasma creatinine concentration greater than 1.5 mg/dL, a fasting triglyceride level greater than 300 mg/dL, or chronic liver disease, were excluded from the study. RESULT: The mean level of LDL cholesterol was significantly decreased, and the percentage of patients who achieved the normal LDL cholesterol level was increased in this study. The mean HDL cholesterol level after statin treatment was decreased by 2.3%. The percent change of HDL cholesterol was affected by baseline HDL cholesterol level, percent change of total cholesterol, percent change of LDL cholesterol, and baseline total cholesterol level. When subjects were divided into quintiles according to baseline HDL cholesterol, HDL cholesterol level was found to be increased in the lowest two quintiles while it was decreased in the highest two quintiles. CONCLUSIONS: There were some patients whose HDL cholesterol level was decreased after statin treatment, depending on their baseline HDL cholesterol level. We think further study on the effect of statins on HDL level will be needed in the future.

A Case of a Gastric Gastrointestinal Stromal Tumor with a Fistula and Gastrointestinal Bleeding / 대한소화기내시경학회지

There has been much debate on the origin, differentiation and prognosis of gastrointestinal stromal tumors (GIST). Based on recent studies, we consider Cajal interstitial cell as the origin of a GIST. The common symptoms of a GIST are abdominal pain, hemorrhage, and the presence of a mass. However, there are few reported cases of a GIST with abscess pockets that communicate with the lumen of the stomach via a fistula. We report a case of a GIST of the stomach presenting with an abscess and a fistula communicating with the lumen of the stomach. An 84-year-old man presented with continuous fever and general weakness. We were able to diagnose the disease by an endoscopic examination, CT scan, biopsy and by cellular immunohistochemical staining.

Quantitative Assessment of Left Atrial Functional Changes in Patients with Atrial Fibrillation by Tissue Doppler Strain and 2-Dimensional Strain Imaging

BACKGROUND AND OBJECTIVES: Conservation of the normal atrial size and architecture by preventing the structural atrial remodeling that's due to atrial fibrillation (AF) seems to be of prime importance for the management of AF patients. We attempted to assess the relevance of performing strain echocardiography for quantitatively assessing the left atrial (LA) status in AF patients. SUBJECTS AND METHODS: Tissue Doppler strain and 2-dimensional strain imaging were performed in 15 patients with chronic AF, in 15 patients with paroxysmal AF and in 15 healthy age-matched controls with using a GE vivid 7 dimension apparatus. The LA diameter, LA volume index and mitral inflow parameters were measured by standard echocardiography. Longitudinal peak strain and the strain rate were obtained from 2 different areas of the basal left atrial free wall and also the inter-atrial septum in the apical 4 chamber view with using the tissue Doppler strain. The mean peak systolic rate (Sm-SR), the peak early diastolic rate (Em-SR) and the peak late diastolic strain rate (Am-SR) were measured at the inter-atrial septum in the apical 4 chamber view with using the 2-dimensional strain imaging. RESULTS: The peak strain/rate, the Sm-SR and the Em-SR were significantly reduced in the AF group as compared with the normal controls, and they were especially reduced in the chronic AF group. There were no significant differences for the LA size and A wave velocity between the paroxysmal AF group and the normal group; however, the peak systolic strain/rate, the Em-SR and the Am-SR were significantly lower in the paroxysmal AF group than in the normal controls. CONCLUSION: The lower values of atrial Sm-SR, Em-SR and Am-SR revealed that active contraction and passive stretching of the LA wall may be impaired in some patients suffering with paroxysmal AF even before LA enlargement occurs, and this is possibly because of reduced atrial compliance. Our results indicated that strain echocardiography enabled quantitatively precise assessment of the LA contractile function and it can provide clinically useful information concerning the early reversible atrial functional changes in patients suffering with AF, and especially in the paroxysmal AF patients.

A Case of Sigmoid Volvulus Treated by Emergency Endoscopic Reduction and Surgical Colonic Resection / 대한소화기내시경학회지

An intestinal obstruction is a common cause of acute abdominal diseases which need emergency measures. Sigmoid volvulus is one of rare causes of colonic obstruction and occupies 2~3% of its causes in Korea. Volvulus requires a prompt diagnosis and decompression in order to prevent its progression to strangulation and gangrene. Although 90% of sigmoid volvulus can be diagnosed just by plain abdominal x-ray, computed tomography or barium enema can be done for more accurate diagnoses. For the successful treatment, accurate early examination, endoscopic reduction and surgical colonic resection are required. Endoscopic reduction has low mortality but is liable to recur, whereas emergency colonic resection has little recurrence rate but a high mortality. We experienced a case of a sigmoid volvulus in a 55-year-old male who companied of sudden abdominal pain. After diagnosed as sigmoid volvulus through plain abdominal x-ray and abdominal computed tomography, endoscopic reduction was done in the early period of development, and the sigmoid resection was performed after 7 days. We report our experience with a review of the literature regarding the diagnosis and treatment of sigmoid volvulus.